# Event Details - **Event Name**: Onsite In-Silico Clinical Trials with NLME Models| Leiden, Netherlands - **Event Start and End Date**: Tue, 07 Apr, 2026 at 09:00 am – Tue, 07 Apr, 2026 at 05:00 pm (+02:00) - **Event Description**: A Hands-On Workshop for Building and Validating In Silico Clinical Trials in PumasAbout this EventDescriptionLearn to design and execute In Silico Clinical Trials (ISCTs) using Pumas and Julia. This intensive one-day workshop guides participants through a complete 7-step ISCT workflow—from building mechanistic QSP models to generating calibrated virtual populations and running virtual clinical trials. Using two disease models (tumor burden and HBV), participants will be introduced to copula sampling, MILP-based population calibration, global sensitivity analysis, and bootstrap inference for treatment effect estimation. Hands-on exercises ensure you leave with practical skills to apply ISCTs to your own drug development programs.ISCTs represent a powerful paradigm shift in drug development, enabling researchers to simulate clinical outcomes across diverse virtual patient populations before committing resources to expensive real-world trials. This workshop provides a comprehensive, hands-on introduction to the complete ISCT workflow using Julia and the Pumas pharmacometrics platform.Based on the methodology published in *CPT: Pharmacometrics & Systems Pharmacology* (Cortés-Ríos et al., 2025), this workshop translates a validated 7-step framework into practical skills. Participants will work through two progressively complex disease models: a tumor burden model that introduces core concepts, and an 11-ODE Hepatitis B virus (HBV) QSP model that demonstrates real-world complexity.What You Will LearnBuild QSP Models in Pumas: Define disease progression and drug PK/PD using the Pumas `model` macro with proper NLME parameterizationConduct Global Sensitivity Analysis: Identify influential parameters using Sobol and eFAST methods to focus model development effortsGenerate Virtual Populations: Sample correlated parameters using copulas while preserving clinically-observed distributionsCalibrate to Clinical Data: Use Mixed-Integer Linear Programming (MILP) to select virtual patients matching target clinical distributionsRun Virtual Clinical Trials: Simulate multi-arm trials with treatment phases and calculate clinical endpointsQuantify Uncertainty: Apply bootstrap inference for confidence intervals on treatment effectsWho Should AttendPharmacometricians transitioning to QSP modelingQuantitative systems pharmacologists building virtual patient workflowsClinical pharmacologists designing virtual trialsComputational biologists working on drug development pipelinesAnyone interested in leveraging in silico methods for clinical trial optimizationPrerequisitesWorking knowledge of Julia and basic Pumas modeling (or equivalent experience with NLME frameworks)Understanding of pharmacokinetic/pharmacodynamic and QSP conceptsFamiliarity with ordinary differential equationsLaptopMaterials ProvidedComplete Pumas codebase with ISCTWorkflow moduleQuarto based tutorials covering theory and implementationExecutable example scripts with annotated codeExercise solutions for self-studyReference documentation for all module functionsPumas 2.8 trial licenseReferenceCortés-Ríos, J., Magee, M., Sher, A., Jusko, W. J., & Desikan, R. (2025). A Step-by-Step Workflow for Performing In Silico Clinical Trials With Nonlinear Mixed Effects Models. *CPT: Pharmacometrics & Systems Pharmacology*. DOI: [10.1002/psp4.70122](https://doi.org/10.1002/psp4.70122)Notes:Please note that these workshops are intended for attendees from academic or industry backgrounds. We kindly request that you register using your institutional or work email address, as this same address will be used to grant you access to Pumas products. If you have any questions or concerns, feel free to reach out to us.Pricing: $500 for Industry, $100 for AcademiaBring Your Team, Save More! Groups of 3+ qualify for a group discount. Email sales@pumas.ai to inquire. - **Event URL**: https://allevents.in/leiden/onsite-in-silico-clinical-trials-with-nlme-models|-leiden-netherlands/100001980170903477 - **Event Categories**: workshops, virtual-run, performances, entertainment, virtual, it - **Interested Audience**: - total_interested_count: 0 ## Ticket Details - **Ticket URL**: https://consumer.pxf.io/c/1339408/3151484/39691?partnerpropertyid=1191892&MediaPartnerPropertyId=1191892&svlink=14105511&level=1&u=https%3A%2F%2Fwww.eventbrite.com%2Fe%2Fonsite-in-silico-clinical-trials-with-nlme-models-leiden-netherlands-tickets-1980170903477 - **Ticket Price Range**: min: 108.55, max: 535.38, currency: USD ## Event venue details - **city**: Leiden - **state**: ZH - **country**: Netherlands - **location**: Golden Tulip & Tulip Inn Leiden Centre - **lat**: 52.1671087 - **long**: 4.485239600000001 - **full address**: Golden Tulip & Tulip Inn Leiden Centre, 3 Schipholweg, Leiden, Netherlands ## Event Organizer details - **affiliate_id**: 10 - **organizer**: Pumas-AI, Inc. (https://allevents.in/org/pumas-ai-inc/17623589) ## Event gallery - **Alt text**: banner - **Image URL**: https://cdn-az.allevents.in/events5/banners/2026dc8768162e9835027bc2b390dd7eb945718d4dc080844d508e4bb94f0c83-rimg-w1200-h600-dc016174-gmir.jpg?v=1768265944 - **Alt text**: thumbnail - **Image URL**: https://cdn-az.allevents.in/events5/banners/77a9a5555e9436172139fb253ce113f77d9f60763ce292ca5fe2640c827bab02-rimg-w400-h400-dcfef9f6-gmir.jpg?v=1768265944 ## FAQs - **Q**: When is the event happening? - **A:** Tue, 07 Apr, 2026 at 09:00 am (+02:00) - **Q**: Where is the event happening? - **A:** Golden Tulip & Tulip Inn Leiden Centre, 3 Schipholweg, Leiden, Netherlands - **Q**: What is the ticket price? - **A:** starting from 108.55 up to 535.38 USD - **Q**: Who is organizing the event? - **A:** Pumas-AI, Inc. - **Q**: What type of event is this? - **A:** workshops, virtual-run, performances, entertainment, virtual, it - **Q**: Where can I find ticket details about Onsite In-Silico Clinical Trials with NLME Models| Leiden, Netherlands ? - **A:** You can find ticket details about this event on AllEvents. ## Structured Data (JSON-LD) ```json [ { "@context": "https://schema.org", "@type": "Event", "name": "Onsite In-Silico Clinical Trials with NLME Models| Leiden, Netherlands", "image": "https://cdn-az.allevents.in/events5/banners/2026dc8768162e9835027bc2b390dd7eb945718d4dc080844d508e4bb94f0c83-rimg-w1200-h600-dc016174-gmir.jpg?v=1768265944", "startDate": "2026-04-07T09:00:00+02:00", "endDate": "2026-04-07T17:00:00+02:00", "url": "https://allevents.in/leiden/onsite-in-silico-clinical-trials-with-nlme-models|-leiden-netherlands/100001980170903477", "eventStatus": "https://schema.org/EventScheduled", "location": { "@type": "Place", "name": "Golden Tulip & Tulip Inn Leiden Centre", "address": { "@type": "PostalAddress", "streetAddress": "3 Schipholweg", "postalCode": "2316 XB", "addressLocality": "Leiden", "addressRegion": "ZH", "addressCountry": "NL" }, "geo": { "@type": "GeoCoordinates", "latitude": "52.1671087", "longitude": "4.485239600000001" } }, "eventAttendanceMode": "https://schema.org/OfflineEventAttendanceMode", "description": "A Hands-On Workshop for Building and Validating In Silico Clinical Trials in Pumas", "offers": [ { "@type": "AggregateOffer", "availability": "https://schema.org/InStock", "priceCurrency": "USD", "availabilityStarts": "2026-01-13", "availabilityEnds": "2026-04-07T17:00:00+02:00", "validFrom": "2026-01-13", "lowPrice": "108.55", "highPrice": "535.38", "price": "108.55", "url": "https://allevents.in/leiden/onsite-in-silico-clinical-trials-with-nlme-models|-leiden-netherlands/100001980170903477" }, { "@type": "Offer", "availability": "https://schema.org/InStock", "priceCurrency": "USD", "availabilityStarts": "2026-01-13", "availabilityEnds": "", "validFrom": "2026-01-13", "url": "https://allevents.in/leiden/onsite-in-silico-clinical-trials-with-nlme-models|-leiden-netherlands/100001980170903477", "price": "535.38", "name": "Industry" }, { "@type": "Offer", "availability": "https://schema.org/InStock", "priceCurrency": "USD", "availabilityStarts": "2026-01-13", "availabilityEnds": "", "validFrom": "2026-01-13", "url": "https://allevents.in/leiden/onsite-in-silico-clinical-trials-with-nlme-models|-leiden-netherlands/100001980170903477", "price": "108.55", "name": "Academia" } ], "organizer": [ { "@type": "Organization", "name": "Pumas-AI Inc.", "url": "https://allevents.in/org/pumas-ai-inc/17623589", "description": "Pumas-AI’s vision is to double pharmaceutical and patient care success by democratizing tools and education in the health care data analytics space. 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